製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab85275 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The Specific activity of ab85275 was determined to be 6.2 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

  • 製品の状態
    Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Cancer/testis antigen 84
    • CT84
    • Epididymis luminal protein 164
    • FLJ14385
    • HEL164
    • Lymphokine activated killer T cell originated protein kinase
    • Lymphokine-activated killer T-cell-originated protein kinase
    • MAPKK like protein kinase
    • MAPKK-like protein kinase
    • Nori 3
    • Nori-3
    • Nori3
    • PBK
    • PDZ binding kinase
    • PDZ-binding kinase
    • Serine/threonine protein kinase
    • Spermatogenesis related protein kinase
    • Spermatogenesis-related protein kinase
    • SPK
    • T LAK cell originated protein kinase
    • T-LAK cell-originated protein kinase
    • TOPK
    • TOPK_HUMAN
    see all
  • 機能
    Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
  • 組織特異性
    Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
  • 配列類似性
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Phosphorylated; in a cell-cycle dependent manner at mitosis.
  • Information by UniProt

画像

  • The Specific activity of ab85275 was determined to be 6.2 nmol/min/mg.
  • SDS-PAGE showing ab85275 at approximately 68kDa.

参考文献

ab85275 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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