Recombinant Human PAX6 protein (ab98302)



  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P26367
    • 生物種Human
    • 分子量23 kDa
    • 領域1 to 209



Our Abpromise guarantee covers the use of ab98302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション


    Western blot

    Indirect ELISA

  • 精製度> 90 % SDS-PAGE.
    ab98302 was purified using IMAC column purification.
  • 製品の状態Liquid
  • 備考This product is for Research Use Only and not to be used for any commercial resale purpose, including, but not limited to, using the product as part of any developed assay technology such as ELISA, ELISPOT, or Multiplex assay that is sold to another end-user.
  • Concentration information loading...


  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: PBS (8.1mM Dibasic monohydrogen sodium phosphate, 500mM Sodium chloride, 2.7mM Potassium chloride, 1.5mM Monobasic dihydrogen potassium phosphate, pH 7.4)


  • 別名
    • AN
    • AN 2
    • AN2
    • Aniridia type II protein
    • D11S812E
    • FVH1
    • MGC17209
    • MGDA
    • Oculorhombin
    • Paired box 6
    • Paired Box Gene 6
    • Paired box gene 6 (aniridia keratitis)
    • Paired box homeotic gene 6
    • Paired box protein Pax-6
    • Paired box protein Pax6
    • PAX 6
    • PAX6
    • PAX6_HUMAN
    • Sey
    • WAGR
    see all
  • 機能Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
  • 組織特異性Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
  • 関連疾患Defects in PAX6 are the cause of aniridia (AN) [MIM:106210]. A congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time.
    Defects in PAX6 are a cause of Peters anomaly (PAN) [MIM:604229]. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
    Defects in PAX6 are a cause of foveal hypoplasia (FOVHYP) [MIM:136520]. Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant.
    Defects in PAX6 are a cause of keratitis hereditary (KERH) [MIM:148190]. An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization.
    Defects in PAX6 are a cause of coloboma ocular (COLO) [MIM:120200]; also known as uveoretinal coloboma or coloboma of iris, choroid and retina. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Severe colobomatous malformations may cause as much as 10% of the childhood blindness. The clinical presentation of ocular coloboma is variable. Some individuals may present with minimal defects in the anterior iris leaf without other ocular defects. More complex malformations create a combination of iris, uveoretinal and/or optic nerve defects without or with microphthalmia or even anophthalmia.
    Defects in PAX6 are a cause of coloboma of optic nerve (COLON) [MIM:120430].
    Defects in PAX6 are a cause of bilateral optic nerve hypoplasia (BONH) [MIM:165550]; also known as bilateral optic nerve aplasia. A congenital anomaly in which the optic disc appears abnormally small. It may be an isolated finding or part of a spectrum of anatomic and functional abnormalities that includes partial or complete agenesis of the septum pellucidum, other midline brain defects, cerebral anomalies, pituitary dysfunction, and structural abnormalities of the pituitary.
    Defects in PAX6 are a cause of aniridia cerebellar ataxia and mental deficiency (ACAMD) [MIM:206700]; also known as Gillespie syndrome. A rare condition consisting of partial rudimentary iris, cerebellar impairment of the ability to perform coordinated voluntary movements, and mental retardation.
  • 配列類似性Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 paired domain.
  • 発生段階Expressed in the developing eye and brain.
  • 翻訳後修飾Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human PAX6 protein 画像

  • SDS-PAGE analysis of 5µg ab98302. PAX6 has been shown to run at an apparent molecular weight higher than predicted.
  • PAX6 monoclonal antibody at 1 µg/ml + ab98302 at 50ng
  • Indirect ELISA detection of ab98302 with titrated amounts of PAX6 monoclonal antibody.

Recombinant Human PAX6 protein (ab98302) 使用論文

ab98302 has not yet been referenced specifically in any publications.

Product Wall

This protein is not conjugated to any fluorophores or enzymes, however, it does contain a 6x his tag.