製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q96IZ0
    • 生物種Human
    • 配列SVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVV RERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKT LLKVVGQLTR
    • 分子量38 kDa including tags
    • 領域231 to 340
    • タグGST tag N-Terminus

関連製品

特性

Our Abpromise guarantee covers the use of ab114724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • 2310001G03Rik
    • PAR 4
    • PAR-4
    • Pawr
    • PAWR_HUMAN
    • PRKC Apoptosis WT1 Regulator
    • PRKC apoptosis WT1 regulator protein
    • Prostate apoptosis response 4 protein
    • Prostate apoptosis response protein 4
    • prostate apoptosis response protein PAR-4
    • Transcriptional repressor Par-4-like protein PAWR
    • Transcriptional repressor PAR4
    • WT1 Interacting Protein
    see all
  • 機能Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
  • 組織特異性Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
  • ドメインThe leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
    The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells.
  • 翻訳後修飾Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
  • 細胞内局在Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.
  • Information by UniProt

Recombinant Human PAR4 protein 画像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human PAR4 protein (ab114724) 使用論文

ab114724 has not yet been referenced specifically in any publications.

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