Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs
Serine threonine kinase PAK 4
Serine/threonine protein kinase PAK 4
Serine/threonine protein kinase PAK4
Serine/threonine-protein kinase PAK 4
機能Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.
組織特異性Highest expression in prostate, testis and colon.
配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CRIB domain. Contains 1 protein kinase domain.
翻訳後修飾Autophosphorylated on serine residues when activated by CDC42/p21. Phosphorylated on tyrosine residues upon stimulation of FGFR2.