製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P07237
    • 生物種Human
    • 分子量58 kDa
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab115719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性>200U/mg
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab115719 is purified by multi-step chromatography.
  • 製品の状態Liquid
  • 備考 >200U/mg
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.61% Tris, 0.88% Sodium chloride, 5% Glycerol, 0.02% DTT, 0.03% EDTA

関連情報

  • 別名
    • Cellular thyroid hormone binding protein
    • Cellular thyroid hormone-binding protein
    • Collagen prolyl 4 hydroxylase beta
    • Disulphide Isomerase
    • DSI
    • EC 5.3.4.1
    • Endoplasmic reticulum resident protein 59
    • ER protein 59
    • ERBA2L
    • ERp59
    • GIT
    • Gltathione insulin transhydrogenase
    • Glutathione insulin transhydrogenase
    • P4HB
    • P4Hbeta
    • p55
    • PDI
    • PDIA1
    • PDIA1_HUMAN
    • PDIR
    • PHDB
    • PO4DB
    • PO4HB
    • Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (protein disulfide isomerase associated 1)
    • Procollagen proline 2 oxoglutarate 4 dioxygenase beta subunit
    • PROHB
    • Prolyl 4 hydroxylase beta polypeptide
    • Prolyl 4 hydroxylase beta subunit
    • Prolyl 4 hydroxylase subunit beta
    • Prolyl 4-hydroxylase subunit beta
    • Protein disulfide isomerase associated 1
    • Protein disulfide isomerase, family A, member 1
    • Protein disulfide isomerase/oxidoreductase
    • Protein disulfide-isomerase
    • Protocollagen hydroxylase
    • Thbp
    • Thyroid hormone binding protein p55
    • Thyroid hormone binding protein p55 cellular
    • V erb a avian erythroblastic leukemia viral oncogene homolog 2 like
    see all
  • 機能This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
  • 配列類似性Belongs to the protein disulfide isomerase family.
    Contains 2 thioredoxin domains.
  • 細胞内局在Endoplasmic reticulum lumen. Melanosome. Cell membrane. Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Recombinant Human P4HB protein 画像

  • SDS-PAGE analysis
    Lane 1: MW marker
    Lane 2: ab115719 at 0.5 µg
    Lane 3: ab115719 at 1 µg
    Lane 4: ab115719 at 2 µg
    Lane 5: ab115719 at 5 µg
  • Monoclonal mouse P4HB antibody + Recombinant Human P4HB protein (ab115719) at 0.05 µg

Recombinant Human P4HB protein (ab115719) 使用論文

ab115719 has not yet been referenced specifically in any publications.

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