製品の概要

  • 製品名Recombinant Human P protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q04671
    • 生物種Human
    • 配列GKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREE HIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRE TV
    • 分子量37 kDa including tags
    • 領域201 to 300

特性

Our Abpromise guarantee covers the use of ab116803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    Western blot

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • BEY
    • BEY1
    • BEY2
    • BOCA
    • D15S12
    • EYCL
    • EYCL2
    • EYCL3
    • eye color 2 (central brown)
    • eye color 3 (brown)
    • hair color 3 (brown)
    • HCL3
    • Melanocyte-specific transporter protein
    • OCA2
    • oculocutaneous albinism II
    • oculocutaneous albinism II (pink-eye dilution homolog, mouse)
    • P
    • P protein
    • P_HUMAN
    • PED
    • Pink eyed dilution protein homolog
    • Pink-eyed dilution protein homolog
    • SHEP1
    • total brown iris pigmentation
    see all
  • 機能Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
  • 関連疾患Defects in OCA2 are the cause of albinism oculocutaneous type 2 (OCA2) [MIM:203200]. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light brown hair and skin color and gray to tan irides.
  • 配列類似性Belongs to the CitM (TC 2.A.11) transporter family.
  • 細胞内局在Melanosome membrane.
  • Information by UniProt

Recombinant Human P protein 画像

  • 12.5% SDS-PAGE showing ab116803 at approximately 36.63kDa.
    Stained with Coomassie Blue.

Recombinant Human P protein (ab116803) 使用論文

ab116803 has not yet been referenced specifically in any publications.

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