製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSEL LKRTALHGESNSVLIIGPRGSGKTMLISHALKELMEIEEVSENVLQVHLN GLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTS SCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILE LLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEK
    • 分子量
      53 kDa including tags
    • 領域
      1 to 248

特性

Our Abpromise guarantee covers the use of ab114619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog of
    • FLJ46668
    • HSORC4
    • ORC 4
    • ORC 4L
    • ORC 4P
    • ORC4
    • ORC4_HUMAN
    • ORC4L
    • ORC4L protein
    • ORC4P
    • Origin recognition complex subunit 4
    • Origin recognition complex subunit 4 (yeast homolog) like
    • Origin recognition complex subunit 4 like
    • Origin recognition complex subunit 4 like (yeast)
    • origin recognition complex, subunit 4 homolog
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog-like
    see all
  • 機能
    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • 関連疾患
    Defects in ORC4 are the cause of Meier-Gorlin syndrome type 2 (MGORS2) [MIM:613800]. MGORS2 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • 配列類似性
    Belongs to the ORC4 family.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • ab114619 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

参考文献

ab114619 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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