製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q13516
    • 生物種Human
    • 配列MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPE LSAELRGAMGSAGAHPVDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIA TLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPA ATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPS VGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV PPPHHHVSAMGAGSLPRLTSDAK
    • 分子量62 kDa including tags
    • 領域1 to 323

特性

Our Abpromise guarantee covers the use of ab112389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Other

    Western blot

  • 製品の状態Liquid
  • 備考Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

関連情報

  • 別名
    • Basic domain helix loop helix protein class B 1
    • Basic helix loop helix protein class B 1
    • BHLHB
    • bHLHB1
    • bHLHe19
    • Class B basic helix loop helix protein 1
    • Class B basic helix-loop-helix protein 1
    • class E basic helix loop helix protein 19
    • Class E basic helix-loop-helix protein 19
    • Human protein kinase C binding protein RACK17
    • Olig2
    • OLIG2_HUMAN
    • Oligo2
    • Oligodendrocyte lineage transcription factor 2
    • Oligodendrocyte specific bHLH transcription factor 2
    • Oligodendrocyte transcription factor 2
    • OTTHUMP00000067569
    • OTTHUMP00000067570
    • PRKCBP2
    • Protein kinase C binding protein 2
    • Protein kinase C binding protein RACK17
    • Protein kinase C-binding protein 2
    • Protein kinase C-binding protein RACK17
    • RACK17
    see all
  • 機能Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
  • 組織特異性Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
  • 関連疾患Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
  • 配列類似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • ドメインThe bHLH is essential for interaction with NKX2-2.
  • 細胞内局在Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
  • Information by UniProt

Recombinant Human Olig2 protein 画像

  • 12.5% SDS-PAGE analysis of ab112389. Stained with Coomassie Blue.

Recombinant Human Olig2 protein (ab112389) 使用論文

ab112389 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112389.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"