Solute carrier organic anion transporter family member 1B1
機能Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
組織特異性Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
配列類似性Belongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain.
細胞内局在Basolateral cell membrane. Detected in basolateral membranes of hepatocytes.