製品の概要

  • 製品名
    Recombinant Human NUDT3 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHH SSGLVPRGSH MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR
    • 分子量
      22 kDa including tags
    • 領域
      1 to 172
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab103915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

    SDS-PAGE

  • 質量分析
    MALDI-TOF
  • 精製度
    > 95 % SDS-PAGE.
    Purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 5mM DTT, 200mM Sodium chloride, 20mM Tris HCl, pH 8

関連情報

  • 別名
    • 5''''-P1
    • Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1
    • Diadenosine 5''
    • Diphosphoinositol polyphosphate phosphohydrolase
    • Diphosphoinositol polyphosphate phosphohydrolase 1
    • DIPP
    • DIPP 1
    • DIPP-1
    • DIPP1
    • Nucleoside diphosphate linked moiety X motif 3
    • Nucleoside diphosphate-linked moiety X motif 3
    • Nudix (nucleoside diphosphate linked moiety X) type motif 3
    • Nudix motif 3
    • Nudix type motif 3
    • NUDT 3
    • Nudt3
    • NUDT3_HUMAN
    • P6-hexaphosphate hydrolase 1
    see all
  • 機能
    Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
  • 組織特異性
    Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
  • 配列類似性
    Belongs to the Nudix hydrolase family. DIPP subfamily.
    Contains 1 nudix hydrolase domain.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

画像

  • 15% SDS-PAGE analysis of ab103915 (3 µg).

参考文献

ab103915 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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