製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      110 kDa including tags
    • 領域
      1 to 628

特性

Our Abpromise guarantee covers the use of ab105209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The Specific activity of ab105209 was determined to be 80 nmol/min/mg.
  • アプリケーション

    SDS-PAGE

    Western blot

    Functional Studies

  • 精製度
    > 75 % SDS-PAGE.
    Purity was determined to be >75% by densitometry.
  • 製品の状態
    Liquid
  • 備考

    ab204854 (Cdc25C peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • DKFZp434J037
    • DKFZp686F01113
    • FLJ90349
    • NUAK family SNF1 like kinase 2
    • NUAK family SNF1-like kinase 2
    • Nuak2
    • NUAK2_HUMAN
    • Omphalocele kinase 2
    • SNARK
    • SNF1/AMP activated protein kinase
    • SNF1/AMP kinase related kinase
    • SNF1/AMP kinase-related kinase
    see all
  • 機能
    Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
  • 配列類似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.
  • Information by UniProt

画像

  • The Specific activity of ab105209 was determined to be 80 nmol/min/mg.
  • SDS-PAGE showing ab105209 at approximately 110kDa.

参考文献

ab105209 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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