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別名
- Linker for activation of B cells
- Linker for activation of B-cells
- Linker for activation of T cells family member 2
- Linker for activation of T cells transmembrane adaptor 2
- Linker for activation of T-cells family member 2
- Membrane associated adapter molecule
- Membrane-associated adapter molecule
- Non T cell activation linker
- Non-T-cell activation linker
- NTAL_HUMAN
- WBSCR 5
- Wbscr15
- Williams Beuren syndrome chromosome region 15
- Williams Beuren syndrome chromosome region 5
- Williams-Beuren syndrome chromosomal region 15 protein
- Williams-Beuren syndrome chromosomal region 5 protein
- WSCR5
see all
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機能
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
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組織特異性
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
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関連疾患
Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
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翻訳後修飾
Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
May be polyubiquitinated.
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細胞内局在
Cell membrane. Present in lipid rafts.
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Information by UniProt