Recombinant Human NTAL protein (ab95498)

関連情報

• 別名
  • HSPC046
  • LAB
  • LAT2

  • Linker for activation of B cells
  • Linker for activation of B-cells
  • Linker for activation of T cells family member 2
  • Linker for activation of T cells transmembrane adaptor 2
  • Linker for activation of T-cells family member 2
  • Membrane associated adapter molecule
  • Membrane-associated adapter molecule
  • Non T cell activation linker
  • Non-T-cell activation linker
  • NTAL_HUMAN
  • WBSCR 5
  • Wbscr15
  • Williams Beuren syndrome chromosome region 15
  • Williams Beuren syndrome chromosome region 5
  • Williams-Beuren syndrome chromosomal region 15 protein
  • Williams-Beuren syndrome chromosomal region 5 protein
  • WSCR5

  see all
• 機能Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
• 組織特異性Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
• 関連疾患Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
• 翻訳後修飾Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
  May be polyubiquitinated.
• 細胞内局在Cell membrane. Present in lipid rafts.

• Target information above from: UniProt accession Q9GZY6 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt