The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: PBS, 1mM EDTA
New ras effector 1
Novel Ras effector 1
RAP1 Binding Protein
Ras association (RalGDS/AF 6) domain family 5
Ras association (RalGDS/AF 6) domain family member 5
Ras association domain containing family protein 5
Ras association domain-containing protein 5
Ras effector like protein
Regulator for cell adhesion and polarization enriched in lymphoid tissue
Regulator for cell adhesion and polarization enriched in lymphoid tissues
Tumor suppressor RASSF3
機能Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
組織特異性Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.