製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 領域188 to 390

関連製品

特性

Our Abpromise guarantee covers the use of ab90277 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS, 1mM EDTA

関連情報

  • 別名
    • Maxp 1
    • MAXP1
    • MGC10823
    • MGC17344
    • New ras effector 1
    • NORE 1
    • NORE1A
    • NORE1B
    • Novel Ras effector 1
    • RAP1 Binding Protein
    • RAPL
    • Ras association (RalGDS/AF 6) domain family 5
    • Ras association (RalGDS/AF 6) domain family member 5
    • Ras association domain containing family protein 5
    • Ras association domain-containing protein 5
    • Ras effector like protein
    • RASF5_HUMAN
    • RASSF 3
    • RASSF 5
    • RASSF3
    • RASSF5
    • Regulator for cell adhesion and polarization enriched in lymphoid tissue
    • Regulator for cell adhesion and polarization enriched in lymphoid tissues
    • Tumor suppressor RASSF3
    see all
  • 機能Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
  • 組織特異性Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
  • 配列類似性Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-associating domain.
    Contains 1 SARAH domain.
  • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
  • Information by UniProt

Recombinant Human NORE1 protein (ab90277) 使用論文

ab90277 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab90277.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"