Recombinant Human NKIRAS2 protein (ab124599)

製品の概要

  • 製品名
    Recombinant Human NKIRAS2 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHH SSGLVPRGSH MGSHMGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQ VRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQE QRRVDPDVAQ HWAKSEKVKL WEVSVADRRS LLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG
    • 分子量
      24 kDa including tags
    • 領域
      1 to 191
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab124599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    > 90 % SDS-PAGE.
    ab124599 is purified by using conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • DKFZP434N1526
    • I kappa B interacting Ras like protein 2
    • I-kappa-B-interacting Ras-like protein 2
    • Kappa B Ras protein 2
    • Kappa B-Ras protein 2
    • KappaB Ras2
    • KappaB-Ras2
    • KBRAS 2
    • KBRAS2
    • KBRS2_HUMAN
    • MGC74742
    • NF kappa B inhibitor interacting Ras like protein 2
    • NF-kappa-B inhibitor-interacting Ras-like protein 2
    • NFKB inhibitor interacting Ras like 2
    • NFKB inhibitor interacting Ras like protein 2
    • NKIRAS 2
    • NKIRAS2
    see all
  • 機能
    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 組織特異性
    Widely expressed.
  • 配列類似性
    Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
  • ドメイン
    In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

Recombinant Human NKIRAS2 protein 画像

  • 15% SDS-PAGE showing ab124599 (3µg).

Recombinant Human NKIRAS2 protein (ab124599) 使用論文

ab124599 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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