Recombinant Human NKIRAS1 protein (ab123143)

製品の概要

  • 製品名Recombinant Human NKIRAS1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9NYS0
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMGKGCKVVVCGLLSVGKTAILEQLLYGNHT IGMEDCETMEDVYMASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFAD GFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKIDLSEQRQV DAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP GRKNKGNSNSEN
    • 分子量24 kDa including tags
    • 領域1 to 192
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab123143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab123143 was purified using conventional chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol

関連情報

  • 別名
    • 2400004O09Rik
    • I kappa B interacting Ras like protein 1
    • I-kappa-B-interacting Ras-like protein 1
    • Kappa B Ras 1
    • Kappa B Ras protein 1
    • Kappa B-Ras protein 1
    • KappaB Ras1
    • KappaB-Ras1
    • KBRAS 1
    • KBRAS1
    • KBRS1_HUMAN
    • NF kappa B inhibitor interacting Ras like protein 1
    • NF-kappa-B inhibitor-interacting Ras-like protein 1
    • NFKB inhibitor interacting Ras like 1
    • NFKB inhibitor interacting Ras like protein 1
    • NKIRAS 1
    • nkiras1
    see all
  • 機能Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
  • ドメインIn contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human NKIRAS1 protein 画像

  • 12% SDS PAGE, 3 µg of ab123143 loaded.

Recombinant Human NKIRAS1 protein (ab123143) 使用論文

ab123143 has not yet been referenced specifically in any publications.

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