製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMTKIKADPDGPEAQAEACSGERTYQELLVN QNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMV LAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVK PHEEYQEAYDECLEEVQSLPLPL
    • 分子量
      19 kDa including tags
    • 領域
      1 to 153
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab102027 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    > 90 % SDS-PAGE.
    ab102027 was purified using conventional chromatography.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

関連情報

  • 別名
    • DKCB2
    • FLJ20479
    • H/ACA ribonucleoprotein complex subunit 2
    • NHP2
    • NHP2 like protein
    • NHP2 ribonucleoprotein
    • NHP2 ribonucleoprotein homolog
    • NHP2 ribonucleoprotein homolog (yeast) 1
    • NHP2, S. cerevisiae, homolog of
    • NHP2_HUMAN
    • NHP2P
    • NOLA2
    • Nucleolar protein family A member 2
    • Nucleolar protein family A member 2 (H/ACA small nucleolar RNPs)
    • snoRNP protein NHP2
    see all
  • 機能
    Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 組織特異性
    Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
  • 関連疾患
    Dyskeratosis congenita, autosomal recessive, 2
  • 配列類似性
    Belongs to the ribosomal protein L7Ae family.
  • 発生段階
    Transcript peaks at G1/S transition.
  • 細胞内局在
    Nucleus > nucleolus. Nucleus > Cajal body. Also localized to Cajal bodies.
  • Information by UniProt

画像

  • 15% SDS-PAGE analysis of ab102027 (3µg)

参考文献

ab102027 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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