The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Nuclear factor of activated T cells, cytoplasmic 3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Nuclear factor of activated T-cells
T cell transcription factor NFAT4
T-cell transcription factor NFAT4
機能Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
組織特異性Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
配列類似性Contains 1 RHD (Rel-like) domain.
ドメインRel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
翻訳後修飾Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
細胞内局在Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.