機能Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.
組織特異性Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
配列類似性Belongs to the RRM NELF-E family. Contains 1 RRM (RNA recognition motif) domain.
ドメインThe RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.