製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMLVIPPGLSEEEEALQKKFNKLKKKKKALL ALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQAKQLVKSGAISAIKAE TKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQRK SLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSA SPPRSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRER DRDRERDRDRDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAF SPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIA RKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF
    • 分子量
      45 kDa including tags
    • 領域
      1 to 380
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab104637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    > 85 % SDS-PAGE.
    ab104637 is purified using conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

関連情報

  • 別名
    • Major histocompatibility complex gene RD
    • Negative elongation factor E
    • Negative elongation factor polypeptide E
    • NELF e
    • NELF-E
    • Nelfe
    • NELFE_HUMAN
    • Nuclear protein
    • RD
    • RD protein
    • RD RNA binding protein
    • RDP
    • RNA-binding protein RD
    see all
  • 機能
    Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.
  • 組織特異性
    Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
  • 配列類似性
    Belongs to the RRM NELF-E family.
    Contains 1 RRM (RNA recognition motif) domain.
  • ドメイン
    The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.
  • 翻訳後修飾
    Sumoylated.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • 15% SDS-PAGE analysis of 3µg ab104637.
    Note: Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.

参考文献

ab104637 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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