製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      110 kDa including tags
    • 領域
      1 to 645

関連製品

特性

Our Abpromise guarantee covers the use of ab125544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The specific activity of ab125544 was determined to be 25 nmol/min/mg as per activity assay protocol.
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 精製度
    > 90 % SDS-PAGE.
    Assessed by densitometry.
  • 製品の状態
    Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.004% EGTA, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 4932416N14Rik
    • FLJ23495
    • NEK11
    • NEK11_HUMAN
    • NEK11S/L
    • Never in mitosis A-related kinase 11
    • NIMA (never in mitosis gene a) related kinase 11
    • NIMA (never in mitosis gene a)- related kinase 11
    • NIMA related kinase 11L
    • NIMA related kinase 11S
    • NIMA-related kinase 11
    • NimA-related protein kinase 11
    • Serine/threonine-protein kinase Nek11
    see all
  • 機能
    Possible role in S-phase checkpoint mechanism.
  • 組織特異性
    Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
  • 配列類似性
    Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
    Contains 1 protein kinase domain.
  • 発生段階
    Predominantly expressed at S/G2/M phase.
  • 翻訳後修飾
    Phosphorylated.
  • 細胞内局在
    Nucleus. Nucleus > nucleolus. Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.
  • Information by UniProt

画像

  • SDS-PAGE analysis of ab125544.
  • The specific activity of ab125544 was determined to be 25nmol/min/mg.

参考文献

ab125544 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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