製品の概要

  • 製品名Recombinant Human NEIL1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q96FI4
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MPEGPELHLA SQFVNEACRA LVFGGCVEKS SVSRNPEVPF ESSAYRISAS ARGKELRLIL SPLPGAQPQQ EPLALVFRFG MSGSFQLVPR EELPRHAHLR FYTAPPGPRL ALCFVDIRRF GRWDLGGKWQ PGRGPCVLQE YQQFRENVLR NLADKAFDRP ICEALLDQRF FNGIGNYLRA EILYRLKIPP FEKARSVLEA LQQHRPSPEL TLSQKIRTKL QNPDLLELCH SVPKEVVQLG GKGYGSESGE EDFAAFRAWL RCYGMPGMSS LQDRHGRTIW FQGDPGPLAP KGRKSRKKKS KATQLSPEDR VEDALPPSKA PSRTRRAKRD LPKRTATQRP EGTSLQQDPE APTVPKKGRR KGRQAASGHC RPRKVKADIP SLEPEGTSAS
    • 分子量46 kDa including tags
    • 領域1 to 390
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab123204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

    SDS-PAGE

  • 質量分析
    MALDI-TOF
  • 精製度> 90 % SDS-PAGE.
    ab123204 is purified using conventional chromatography.
  • 製品の状態Liquid
  • 備考EC=3.2.2.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.002% PMSF, 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • DNA (apurinic or apyrimidinic site) lyase Neil1
    • DNA glycosylase/AP lyase Neil 1
    • DNA glycosylase/AP lyase Neil1
    • DNA-(apurinic or apyrimidinic site) lyase Neil1
    • Endonuclease 8 like 1
    • Endonuclease 8-like 1
    • Endonuclease VIII
    • Endonuclease VIII like 1
    • Endonuclease VIII-like 1
    • FLJ22402
    • FPG1
    • hFPG1
    • NEH 1
    • NEH1
    • NEI 1
    • Nei endonuclease VIII like 1
    • Nei endonuclease VIII like 1 (E. coli)
    • Nei homolog 1
    • Nei like 1
    • Nei like protein 1
    • Nei-like protein 1
    • NEI1
    • NEIL 1
    • Neil1
    • NEIL1_HUMAN
    see all
  • 機能Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
  • 組織特異性Ubiquitous.
  • 配列類似性Belongs to the FPG family.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human NEIL1 protein 画像

  • 15% SDS-PAGE analysis of ab123204 (3ug)

Recombinant Human NEIL1 protein (ab123204) 使用論文

ab123204 has not yet been referenced specifically in any publications.

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