製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9NXR1-2
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST GGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG GERRPSSTSV PLGDKGLDTS CRWLSKSTTR SSSSC
    • 分子量40 kDa including tags
    • 領域1 to 335
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 85 % SDS-PAGE.
    ab125486 is purified by proprietary chromatographic techniques. Purity is greater than 85.0% as determined by SDS-PAGE.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.08% DTT, 0.32% Tris HCl, 20% Glycerol, 1.17% Sodium chloride

関連情報

  • 別名
    • FLJ20101
    • HOM TES 87
    • LIS1 interacting protein NUDE1
    • LIS1 interacting protein NUDE1 rat homolog
    • LIS4
    • NDE 1
    • NDE1
    • NDE1_HUMAN
    • Nuclear distribution gene E homolog 1
    • Nuclear distribution protein nudE homolog 1
    • NudE
    • NUDE 1
    • NudE nuclear distribution gene E homolog 1
    • NudE nuclear distribution gene E homolog 1 (A. nidulans)
    • NUDE1
    see all
  • 機能Required for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). Required for formation and function of the mitotic spindle.
  • 配列類似性Belongs to the nudE family.
  • 翻訳後修飾Phosphorylated in mitosis.
  • 細胞内局在Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Cleavage furrow. Localizes to the interphase centrosome and to the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis.
  • Information by UniProt

Recombinant Human NDE1 protein (ab125486) 使用論文

ab125486 has not yet been referenced specifically in any publications.

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