The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05µg/µl
This protein is best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Neuroendocrine sodium channel
Peripheral sodium channel 1
Sodium channel protein type 9 subunit alpha
Sodium channel protein type IX subunit alpha
Sodium channel voltage gated type IX alpha
Sodium channel voltage gated type IX alpha polypeptide
Sodium channel voltage gated type IX alpha subunit
Voltage gated sodium channel alpha subunit Nav1.7
Voltage gated sodium channel subunit alpha Nav1
Voltage-gated sodium channel subunit alpha Nav1.7
機能Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).
組織特異性Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.
関連疾患Primary erythermalgia Indifference to pain, congenital, autosomal recessive Paroxysmal extreme pain disorder Generalized epilepsy with febrile seizures plus 7 Febrile seizures, familial, 3B
配列類似性Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. Contains 1 IQ domain.
ドメインThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
翻訳後修飾Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.
細胞内局在Cell membrane. Cell projection. In neurite terminals.