Recombinant Human NADH dehydrogenase subunit 4 protein (ab116897)

製品の概要

  • 製品名
    Recombinant Human NADH dehydrogenase subunit 4 protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      YSLYIFTTTQWGSLTHHINNIKPSFTRENTLMFIHLSPILLLSLNPDIIT GFSS
    • 分子量
      32 kDa including tags
    • 領域
      406 to 459

特性

Our Abpromise guarantee covers the use of ab116897 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • MT-ND4
    • MTND4
    • NADH dehydrogenase subunit 4
    • NADH-ubiquinone oxidoreductase chain 4
    • NADH4
    • ND4
    • NU4M_HUMAN
    see all
  • 機能
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
  • 関連疾患
    Defects in MT-ND4 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
    Defects in MT-ND4 are a cause of Leber hereditary optic neuropathy with dystonia (LDYT) [MIM:500001]; also called familial dystonia with visual failure and striatal lucencies. LDYT is part of a spectrum of Leber hereditary optic neuropathy. It is characterized by the association of optic atrophy and central vision loss with dystonia.
    Defects in MT-ND4 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) [MIM:540000]. MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness.
  • 配列類似性
    Belongs to the complex I subunit 4 family.
  • 細胞内局在
    Mitochondrion membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab116897 at approximately 31.57kDa and stained with Coomassie Blue.

参考文献

ab116897 has not yet been referenced specifically in any publications.

レビューと Q&A

Thank you for contacting us.

As I understand from your email, you were looking for an antibody against NADH dehydrogenase?

ab116897 is not an antibody but a protein expressed from wheat germ. The protein is a recombinant fragment of...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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