製品の概要

  • 製品名Recombinant Human NACA1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q13765
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMPGEATETVPATEQELPQPQAETGSGTESD SDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIED LSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKD IELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM
    • 分子量26 kDa including tags
    • 領域1 to 215
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab113865 was purified by using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.02% DTT, 0.88% Sodium chloride

関連情報

  • 別名
    • Alpha NAC
    • Alpha-NAC
    • Hom s 2.02
    • HSD48
    • MGC117224
    • NAC-alpha
    • naca
    • NACA/1.9.2
    • NACA_HUMAN
    • NACA1
    • Nascent polypeptide associated complex alpha polypeptide
    • Nascent polypeptide associated complex alpha subunit
    • Nascent polypeptide associated complex subunit alpha
    • Nascent polypeptide-associated complex subunit alpha
    see all
  • 機能Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
  • 組織特異性Ubiquitously expressed.
  • 配列類似性Belongs to the NAC-alpha family.
    Contains 1 NAC-A/B (NAC-alpha/beta) domain.
    Contains 1 UBA domain.
  • 翻訳後修飾Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm. Nucleus. Predominantly cytoplasmic. Also found in nucleus.
  • Information by UniProt

Recombinant Human NACA1 protein 画像

  • ab113865 at 3 µg analysed by 15% SDS-PAGE.

Recombinant Human NACA1 protein (ab113865) 使用論文

ab113865 has not yet been referenced specifically in any publications.

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