Recombinant Human Myocilin protein (ab116838)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q99972
    • 生物種Human
    • 配列MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYT FSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLH QLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELETAYSNLLRDKS VLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSR EVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVW VGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFE YDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELN TETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGA IVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVN FAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIK LSKM
    • 分子量82 kDa including tags
    • 領域1 to 504

特性

Our Abpromise guarantee covers the use of ab116838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • GLC1A
    • GPOA
    • JOAG
    • JOAG1
    • Mutated trabecular meshwork-induced glucocorticoid response protein
    • MYOC
    • MYOC_HUMAN
    • Myocilin
    • Myocilin, trabecular meshwork inducible glucocorticoid
    • TIGR
    • Trabecular meshwork induced glucocorticoid response protein
    • Trabecular meshwork-induced glucocorticoid response protein
    see all
  • 機能May participate in the obstruction of fluid outflow in the trabecular meshwork.
  • 組織特異性Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
  • 関連疾患Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
    Defects in MYOC may also contribute to primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
  • 配列類似性Contains 1 olfactomedin-like domain.
  • 翻訳後修飾Different isoforms may arise by post-translational modifications.
    Glycosylated.
    Palmitoylated.
  • 細胞内局在Rough endoplasmic reticulum. Secreted. Cell projection > cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted.
  • Information by UniProt

Recombinant Human Myocilin protein 画像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab116838 at approximately 81.55 kDa.

Recombinant Human Myocilin protein (ab116838) 使用論文

ab116838 has not yet been referenced specifically in any publications.

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