製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab84800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific activity: 270nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

  • 製品の状態Liquid
  • 備考

    ab60014 (Mouse MYL9 full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.00174% PMSF, 0.82% Sodium phosphate, 0.00308% DTT, 25% Glycerol, 1.74% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • KMLC
    • MLCK
    • MLCK, skeletal/cardiac
    • MLCK2
    • MYLK 2
    • MYLK2
    • MYLK2_HUMAN
    • Myosin light chain kinase 2
    • Myosin light chain kinase 2 skeletal muscle
    • Myosin light chain kinase 2 skeletal/cardiac muscle
    • MYOSIN LIGHT POLYPEPTIDE KINASE
    • Myosin light polypeptide kinase, skeletal/cardiac
    • Skeletal muscle myosin light chain kinase
    • Skeletal myosin light chain kinase
    • skeletal/cardiac muscle
    • skMLCK
    see all
  • 機能Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
  • 組織特異性Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
  • 関連疾患Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 細胞内局在Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
  • Information by UniProt

Recombinant human MYLK2 protein 画像

  • Specific activity of ab84800
  • SDS page analysis of ab84800

Recombinant human MYLK2 protein (ab84800) 使用論文

ab84800 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab84800.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"