Recombinant Human Myeloid leukemia factor 1 protein (ab40569)

製品の概要

  • 製品名
    Recombinant Human Myeloid leukemia factor 1 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human

関連製品

特性

Our Abpromise guarantee covers the use of ab40569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.002% Sodium Azide
    Constituents: 0.1% Triton X-100, 10mM Tris, pH 8.0

関連情報

  • 別名
    • Hls7
    • MLF1
    • MLF1_HUMAN
    • Myelodysplasia myeloid leukemia factor 1
    • Myelodysplasia-myeloid leukemia factor 1
    • Myeloid leukemia factor 1
    • myeloid leukemia factor 1 variant 1
    • myeloid leukemia factor 1 variant 2
    • myeloid leukemia factor 1 variant 3
    see all
  • 機能
    Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  • 組織特異性
    Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
  • 関連疾患
    Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
  • 配列類似性
    Belongs to the MLF family.
  • 翻訳後修飾
    Phosphorylation is required for binding to YWHAZ.
  • 細胞内局在
    Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
  • Information by UniProt

Recombinant Human Myeloid leukemia factor 1 protein 画像

  • Analysis of Myeloid leukemia factor 1 Recombinant Protein.
    4-20% SDS gradient gel. Coomassie blue staining.

Recombinant Human Myeloid leukemia factor 1 protein (ab40569) 使用論文

ab40569 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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