Recombinant Human Myeloid leukemia factor 1 protein (ab40569)

製品の概要

  • 製品名Recombinant Human Myeloid leukemia factor 1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human

関連製品

特性

Our Abpromise guarantee covers the use of ab40569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.002% Sodium Azide
    Constituents: 0.1% Triton X-100, 10mM Tris, pH 8.0

関連情報

  • 別名
    • Hls7
    • MLF1
    • MLF1_HUMAN
    • Myelodysplasia myeloid leukemia factor 1
    • Myelodysplasia-myeloid leukemia factor 1
    • Myeloid leukemia factor 1
    • myeloid leukemia factor 1 variant 1
    • myeloid leukemia factor 1 variant 2
    • myeloid leukemia factor 1 variant 3
    see all
  • 機能Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  • 組織特異性Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
  • 関連疾患Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
  • 配列類似性Belongs to the MLF family.
  • 翻訳後修飾Phosphorylation is required for binding to YWHAZ.
  • 細胞内局在Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
  • Information by UniProt

Recombinant Human Myeloid leukemia factor 1 protein 画像

  • Analysis of Myeloid leukemia factor 1 Recombinant Protein.
    4-20% SDS gradient gel. Coomassie blue staining.

Recombinant Human Myeloid leukemia factor 1 protein (ab40569) 使用論文

ab40569 has not yet been referenced specifically in any publications.

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