製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号O15146
    • 生物種Human
    • 分子量63 kDa
    • タグGST tag N-Terminus
    • 配列の追加情報Recombinant fragment from human MUSK, cytoplasmic domain, amino acids 519-end.

関連製品

特性

Our Abpromise guarantee covers the use of ab71693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性

    Specific activity is 6.7 nmol/min/mg.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 製品の状態Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • MDK 4
    • MDK4
    • MGC126323
    • MGC126324
    • Muscle
    • Muscle skeletal receptor tyrosine kinase
    • Muscle skeletal receptor tyrosine protein kinase
    • Muscle specific kinase receptor
    • Muscle specific tyrosine kinase receptor
    • Muscle specific tyrosine protein kinase receptor
    • Muscle-specific kinase receptor
    • Muscle-specific tyrosine-protein kinase receptor
    • MuSK
    • MUSK_HUMAN
    • Neural fold somite kinase 1
    • Neural fold somite kinase 2
    • Neural fold somite kinase 3
    • Neural fold somite kinase1
    • Neural fold somite kinase2
    • Neural fold somite kinase3
    • Nsk 1
    • Nsk 2
    • Nsk 3
    • Nsk1
    • Nsk2
    • Nsk3
    • Receptor tyrosine kinase MuSK
    • Skeletal muscle receptor tyrosine kinase
    • skeletal receptor tyrosine-protein kinase
    see all
  • 機能Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
  • 関連疾患Defects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 FZ (frizzled) domain.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant human MUSK protein 画像

Recombinant human MUSK protein (ab71693) 使用論文

ab71693 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71693.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"