製品の概要

  • 製品名Recombinant Human MTH1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P36639
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMGASRLYTLVLVLQPQRVLLGMKKRGFGAG RWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPEL MDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQK KKFHGYFKFQGQDTILDYTLREVDTV
    • 分子量20 kDa including tags
    • 領域1 to 156
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab99390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab99390 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 2mM DTT, 100mM Sodium chloride, pH 8.0

関連情報

  • 別名
    • 2-hydroxy-dATP diphosphatase
    • 7
    • 7 8 dihydro 8 oxoguanine triphosphatase
    • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase
    • 8 oxo 7 8 dihydroguanosine triphosphatase
    • 8 oxo dGTPase
    • 8-dihydro-8-oxoguanine triphosphatase
    • 8-oxo-dGTPase
    • 8ODP_HUMAN
    • MTH 1
    • MTH1
    • MutT human homolog 1
    • Nucleoside diphosphate linked moiety X motif 1
    • Nucleoside diphosphate linked moiety X type motif 1
    • Nucleoside diphosphate-linked moiety X motif 1
    • Nudix (nucleoside diphosphate linked moiety X) type motif 1
    • Nudix hydrolase 1
    • Nudix motif 1
    • Nudix type motif 1
    • NUDT 1
    • Nudt1
    see all
  • 機能Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
  • 組織特異性Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
  • 配列類似性Belongs to the Nudix hydrolase family.
    Contains 1 nudix hydrolase domain.
  • 発生段階In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
  • 翻訳後修飾The N-terminus is blocked.
  • 細胞内局在Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
  • Information by UniProt

Recombinant Human MTH1 protein 画像

  • 15% SDS-PAGE analysis of 3µg ab99390.

Recombinant Human MTH1 protein (ab99390) 使用論文

ab99390 has not yet been referenced specifically in any publications.

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