Recombinant Human Msx2/Hox8 protein (ab114704)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P35548
    • 生物種Human
    • 配列MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVE ALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFE TASVKSENSEDGAAWMQEPGRYSPPPRHTSPTT
    • 分子量40 kDa including tags
    • 領域1 to 133

関連製品

特性

Our Abpromise guarantee covers the use of ab114704 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • CRS 2
    • CRS2
    • FPP
    • Homeo box msh like 2
    • Homeobox protein Hox-8
    • Homeobox protein MSX 2
    • Homeobox protein MSX-2
    • Homeobox protein MSX2
    • Hox 8
    • Hox8
    • MSH
    • Msh homeo box 2
    • Msh homeo box homolog
    • Msh homeo box homolog 2
    • Msh homeobox 2
    • Msh homeobox homolog 2
    • Msx 2
    • MSX2
    • MSX2_HUMAN
    • Parietal foramina 1
    • PFM
    • PFM 1
    • PFM1
    see all
  • 機能Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
  • 関連疾患Defects in MSX2 are the cause of parietal foramina 1 (PFM1) [MIM:168500]; also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month.
    Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD) [MIM:168550]; also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles.
    Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2) [MIM:604757]; also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal.
  • 配列類似性Belongs to the Msh homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human Msx2/Hox8 protein 画像

  • 12.5% SDS-PAGE showing ab114704 at approximately 40.26 kDa stained with Coomassie Blue.

Recombinant Human Msx2/Hox8 protein (ab114704) 使用論文

ab114704 has not yet been referenced specifically in any publications.

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