製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号O95255
    • 生物種Human
    • 配列IAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAG RRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV
    • 分子量37 kDa including tags
    • 領域831 to 930

関連製品

特性

Our Abpromise guarantee covers the use of ab114729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • ABC34
    • Abcc6
    • Anthracycline resistance-associated protein
    • ARA
    • ATP binding cassette sub family C (CFTR/MRP) member 6
    • ATP binding cassette sub family C member 6
    • ATP-binding cassette sub-family C member 6
    • EST349056
    • MLP1
    • MOAT E
    • MOAT-E
    • MOATE
    • MRP 6
    • MRP6
    • MRP6_HUMAN
    • Multi-specific organic anion transporter E
    • Multidrug resistance associated protein 6
    • Multidrug resistance-associated protein 6
    • multispecific organic anion transporter E
    • PXE
    • PXE1
    • URG7
    • URG7 protein
    see all
  • 機能May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
  • 組織特異性Expressed in kidney and liver. Very low expression in other tissues.
  • 関連疾患Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE).
  • 配列類似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 細胞内局在Membrane. Localized to the basolateral membrane.
  • Information by UniProt

Recombinant Human MRP6 protein 画像

  • 12.5% SDS-PAGE showing ab114729 at approximately 36.63kDa.
    Stained with Coomassie Blue.

Recombinant Human MRP6 protein (ab114729) 使用論文

ab114729 has not yet been referenced specifically in any publications.

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