Recombinant human MNK2 protein (ab51441)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human
    • タグGST tag N-Terminus

関連製品

特性

Our Abpromise guarantee covers the use of ab51441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • G protein coupled receptor kinase 7
    • GPRK7
    • MAP kinase interacting serine threonine kinase
    • MAP kinase interacting serine threonine kinase 2
    • MAP kinase interacting serine threonine protein kinase 2
    • MAP kinase signal integrating kinase 2
    • MAP kinase signal-integrating kinase 2
    • MAP kinase-interacting serine/threonine-protein kinase 2
    • MAPK interacting kinase 2
    • MAPK signal integrating kinase 2
    • Mitogen activated protein kinase interacting serine threonine kinase 2
    • Mknk2
    • MKNK2_HUMAN
    • Mnk2
    • Putative map kinase interacting kinase
    see all
  • 機能May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
  • 組織特異性Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase.
  • Information by UniProt

Recombinant human MNK2 protein 画像

  • Kinase activity assay - specific activity 95 nmol/min/mg.
  • Recombinant human MNK2 protein (tagged). Molecular weight 74 kDa.

Recombinant human MNK2 protein (ab51441) 使用論文

ab51441 has not yet been referenced specifically in any publications.

Product Wall

ab125635 activity was determined using substrate modified-EIF2S peptide.
ab51441 activity was determined using myelin basic protein.

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