Recombinant Human MMP12 protein (ab80209)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MKFLLILLLQATASGALPLNSSTSLEKNNVLFG
    • 領域1 to 33

特性

Our Abpromise guarantee covers the use of ab80209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

  • 再構成Redissolve the powder with 1ml sterile water will restore to the original concentration 1mg/ml.

関連情報

  • 別名
    • EC 3.4.24.65
    • HME
    • Macrophage elastase
    • Macrophage metalloelastase
    • Macrophage metaloelastase
    • Matrix metallopeptidase 12 (macrophage elastase)
    • Matrix metalloprotease 12
    • Matrix metalloproteinase-12
    • ME
    • MGC138506
    • MME
    • MMP 12
    • MMP-12
    • Mmp12
    • MMP12_HUMAN
    see all
  • 機能May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
  • 組織特異性Found in alveolar macrophages but not in peripheral blood monocytes.
  • 配列類似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Recombinant Human MMP12 protein 画像

  • 30% SDS PAGE showing ab80209 at approximately 8 kDa.

Recombinant Human MMP12 protein (ab80209) 使用論文

ab80209 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. The question for the MMP12 protein has been forwarded from the customer servicesto us in the technical team.

We do have another MMP12 protein in our catalog, it is the ab80209. http://www.abcam.com/index.html?data...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"