製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human
    • 領域578 to 872

関連製品

特性

Our Abpromise guarantee covers the use of ab72490 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab72490 was determined to be 1231 nmol/min/mg.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 製品の状態Liquid
  • 備考

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • c MER
    • c mer proto oncogene tyrosine kinase
    • c-mer
    • cMER
    • cmer protooncogene tyrosine kinase
    • Eyk
    • MER
    • MER receptor tyrosine kinase
    • MERK
    • MERPEN
    • Mertk
    • MERTK c-mer proto-oncogene tyrosine kinase
    • MERTK_HUMAN
    • MGC133349
    • nmf12
    • Nyk
    • Proto oncogene tyrosine protein kinase MER
    • Proto oncogene tyrosine protein kinase MER precursor
    • Proto-oncogene c-Mer
    • Receptor tyrosine kinase MerTK
    • RP38
    • STK kinase
    • Tyrosine-protein kinase Mer
    see all
  • 機能In case of filovirus infection, seems to function as a cell entry factor.
  • 組織特異性Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
  • 関連疾患Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant human MERTK protein 画像

  • Kinase Assay demonstrating specific activity of ab72490.
  • SDS-PAGE showing ab72490 at approximately 58kDa.

Recombinant human MERTK protein (ab72490) 使用論文

ab72490 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab72490.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"