Recombinant Human MelanA protein (ab114312)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRR RNGYRALMDKSLHVGTQCALTRRCPQEGFDHRDSKVSLQEKNCEPVVPNA PPAYEKLSAEQSPPPYSP
    • 分子量
      39 kDa including tags
    • 領域
      1 to 118

特性

Our Abpromise guarantee covers the use of ab114312 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Antigen LB39 AA
    • Antigen LB39-AA
    • Antigen SK29 AA
    • Antigen SK29-AA
    • MAR1_HUMAN
    • MART 1
    • MART-1
    • MART1
    • Melan A
    • Melan A protein
    • Melanoma antigen recognized by T cells 1
    • Melanoma antigen recognized by T-cells 1
    • MLAN A
    • MLANA
    • OTTHUMP00000021036
    • OTTHUMP00000021037
    • OTTHUMP00000021038
    • Protein Melan-A
    see all
  • 機能
    Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
  • 組織特異性
    Expression is restricted to melanoma and melanocyte cell lines and retina.
  • 翻訳後修飾
    Acylated.
  • 細胞内局在
    Endoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus > trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
  • Information by UniProt

画像

  • SDS-PAGE analysis of ab114312 on a 12.5% gel stained with Coomassie Blue.

参考文献

ab114312 has not yet been referenced specifically in any publications.

レビューと Q&A

Please note that ab38124 is not a full length protein but a recombinant fragment, corresponding to amino acids 1-150 of Human Melanoma gp100.

As for the stimulation assays, unfortunately we have not tested these proteins in stimulation assays...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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