製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P46734
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS
    • 分子量38 kDa including tags
    • 領域1 to 318
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab125168 is purified by proprietary chromatographic techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol

関連情報

  • 別名
    • AW212142
    • dual specificity mitogen activated protein kinase kinase 3
    • Dual specificity mitogen-activated protein kinase kinase 3
    • MAP kinase kinase 3
    • map2k3
    • MAPK ERK kinase 3
    • MAPK/ERK kinase 3
    • MAPKK 3
    • MAPKK3
    • MEK 3
    • MEK3
    • Mitogen activated protein kinase kinase 3
    • MKK 3
    • MKK3
    • mMKK3b
    • MP2K3_HUMAN
    • PRKMK 3
    • PRKMK3
    • protein kinase, mitogen-activated, kinase 3
    • SAPK kinase 2
    • SAPKK 2
    • SAPKK2
    • Stress activated protein kinase kinase 2
    see all
  • 機能Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
  • 組織特異性Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
  • 関連疾患Note=Defects in MAP2K3 may be involved in colon cancer.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated.
    Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Information by UniProt

Recombinant Human MEK3 protein (ab125168) 使用論文

ab125168 has not yet been referenced specifically in any publications.

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