製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHH SSGLVPRGSH MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS
    • 分子量
      38 kDa including tags
    • 領域
      20 to 347
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab105578 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    > 90 % SDS-PAGE.
    ab105578 was purified using conventional chromatography.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8

関連情報

  • 別名
    • AW212142
    • dual specificity mitogen activated protein kinase kinase 3
    • Dual specificity mitogen-activated protein kinase kinase 3
    • MAP kinase kinase 3
    • map2k3
    • MAPK ERK kinase 3
    • MAPK/ERK kinase 3
    • MAPKK 3
    • MAPKK3
    • MEK 3
    • MEK3
    • Mitogen activated protein kinase kinase 3
    • MKK 3
    • MKK3
    • mMKK3b
    • MP2K3_HUMAN
    • PRKMK 3
    • PRKMK3
    • protein kinase, mitogen-activated, kinase 3
    • SAPK kinase 2
    • SAPKK 2
    • SAPKK2
    • Stress activated protein kinase kinase 2
    see all
  • 機能
    Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
  • 組織特異性
    Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
  • 関連疾患
    Note=Defects in MAP2K3 may be involved in colon cancer.
  • 配列類似性
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Autophosphorylated.
    Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Information by UniProt

画像

  • 15% SDS-PAGE analysis of ab105578 (3ug)

参考文献

ab105578 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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