製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号O00470
    • 生物種Human
    • 配列MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQY PHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALI
    • 分子量36 kDa including tags
    • 領域1 to 90
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab112321 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

関連情報

  • 別名
    • Homeo box protein Meis1
    • Homeobox protein Meis1
    • Leukemogenic homolog protein
    • MEIS 1
    • Meis homeo box 1
    • Meis homeobox 1
    • Meis1
    • Meis1 mouse homolog
    • Meis1 myeloid ecotropic viral integration site 1 homolog
    • Meis1 myeloid ecotropic viral integration site 1 homolog mouse
    • MEIS1 protein
    • MEIS1_HUMAN
    • MGC43380
    • Myeloid ecotropic viral integration site 1 homolog
    • WUGSC:H NH0444B04.1
    see all
  • 機能Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
  • 組織特異性Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
  • 関連疾患Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
  • 配列類似性Belongs to the TALE/MEIS homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human MEIS1 protein 画像

  • ab112321 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human MEIS1 protein (ab112321) 使用論文

ab112321 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"