The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Best use within three months from the date of receipt of this protein.
Concentration information loading...
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione
Homeo box protein Meis1
Homeobox protein Meis1
Leukemogenic homolog protein
Meis homeo box 1
Meis homeobox 1
Meis1 mouse homolog
Meis1 myeloid ecotropic viral integration site 1 homolog
Meis1 myeloid ecotropic viral integration site 1 homolog mouse
Myeloid ecotropic viral integration site 1 homolog
機能Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
組織特異性Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
関連疾患Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
配列類似性Belongs to the TALE/MEIS homeobox family. Contains 1 homeobox DNA-binding domain.