The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
Concentration information loading...
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Cdc47, S. cerevisiae, homolog of
DNA replication licensing factor MCM7
Homolog of S. cerevisiae Cdc47
MCM7 minichromosome maintenance deficient 7
Minichromosome Maintainence 7
Minichromosome maintainence, S. cerevisiae, homolog of
Minichromosome maintenance complex component 7
Minichromosome maintenance deficient 7
Minichromosome maintenance protein 7
機能Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
配列類似性Belongs to the MCM family. Contains 1 MCM domain.
翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.