機能E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
組織特異性Broadly expressed. Present in immature dendritic cells (at protein level).
パスウェイProtein modification; protein ubiquitination.
配列類似性Contains 1 RING-CH-type zinc finger.
ドメインThe RING-CH-type zinc finger domain is required for E3 ligase activity.
細胞内局在Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.