製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Saccharomyces cerevisiae
  • アミノ酸配列
    • 生物種Human
    • 配列MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS KAGSPPSAS APAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCH CTGSLHFVHQACLQQWIKSS DTRCCELCKYEFIMETKLKPLRKWEKLQ MTSSERRKIMCSVTFHVIAITCVVWSLYVLI DRTAEEIKQGQATGILE WPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVI YVQNCP ETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV

関連製品

特性

Our Abpromise guarantee covers the use of ab88197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab88197 was purified using affinity chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

関連情報

  • 別名
    • c MIR
    • c-MIR
    • Cellular modulator of immune recognition
    • E3 ubiquitin protein ligase MARCH8
    • E3 ubiquitin-protein ligase MARCH8
    • MARCH 8
    • MARCH VIII
    • MARCH-VIII
    • MARCH8
    • MARH8_HUMAN
    • Membrane associated RING CH protein VIII
    • Membrane associated ring finger (C3HC4) 8
    • Membrane associated RING finger protein 8
    • Membrane-associated RING finger protein 8
    • Membrane-associated RING-CH protein VIII
    • MIR
    • OTTHUMP00000058921
    • RING finger protein 178
    • RNF178
    see all
  • 機能E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
  • 組織特異性Broadly expressed. Present in immature dendritic cells (at protein level).
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Contains 1 RING-CH-type zinc finger.
  • ドメインThe RING-CH-type zinc finger domain is required for E3 ligase activity.
  • 細胞内局在Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
  • Information by UniProt

Recombinant Human MARCH8 protein (ab88197) 使用論文

ab88197 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"