Recombinant Human MAPKAP Kinase 2 protein (ab45154)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 領域
      46 to 400

特性

Our Abpromise guarantee covers the use of ab45154 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

関連情報

  • 別名
    • MAP kinase activated protein Kinase 2
    • MAP kinase-activated protein kinase 2
    • MAPK activated protein kinase 2
    • MAPK-activated protein kinase 2
    • MAPK2_HUMAN
    • MAPKAP K2
    • MAPKAP kinase 2
    • MAPKAPK 2
    • MAPKAPK-2
    • MAPKAPK2
    • Mitogen activated protein kinase activated protein kinase 2
    • MK 2
    • MK2
    see all
  • 機能
    Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.
  • 組織特異性
    Expressed in all tissues examined.
  • 配列類似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Phosphorylated and activated by MAP kinase.
  • Information by UniProt

画像

参考文献

ab45154 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab45154.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録