製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab45159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 精製度
    > 90 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

関連情報

  • 別名
    • Human p38Beta MAP kinase mRNA complete cds
    • MAP kinase 11
    • MAP kinase p38 beta
    • MAPK 11
    • Mapk11
    • Mitogen activated protein kinase 11
    • Mitogen activated protein kinase p38 2
    • Mitogen activated protein kinase p38 beta
    • Mitogen-activated protein kinase 11
    • Mitogen-activated protein kinase p38 beta
    • MK11_HUMAN
    • p38 2
    • p38-2
    • p38B
    • p38Beta
    • P38BETA2
    • PRKM11
    • Protein kinase mitogen activated 11
    • SAPK2
    • SAPK2B
    • Stress activated protein kinase 2
    • Stress activated protein kinase 2b
    • Stress-activated protein kinase 2
    see all
  • 機能
    Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
  • 組織特異性
    Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 配列類似性
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • ドメイン
    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻訳後修飾
    Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.
  • Information by UniProt

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参考文献

ab45159 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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