COT proto oncogene serine/threonine protein kinase
Ewing sarcoma transformant
Mitogen activated protein kinase kinase kinase 8
Mitogen-activated protein kinase kinase kinase 8
Proto oncogene cCot
Serine/threonine protein kinase cot
Serine/threonine-protein kinase cot
Tumor progression locus 2
Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Expressed in several normal tissues and human tumor-derived cell lines.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain.
Isoform 1 is activated specifically during the S and G2/M phases of the cell cycle.
Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues.