v maf musculoaponeurotic fibrosarcoma oncogene homolog A
v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
機能Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
配列類似性Belongs to the bZIP family. Maf subfamily. Contains 1 bZIP domain.
翻訳後修飾Ubiquitinated, leading to its degradation by the proteasome. Ser-14 and Ser-65 appear to be the major phosphorylation sites. Phosphorylated by MAPK13 on serine and threonine residues (Probable). Phosphorylation by GSK3 requires prior phosphorylation of Ser-65 by another kinase. Phosphorylation proceeds then from Ser-61 to Thr-57, Thr-53 and Ser-49. GSK3-mediated phosphorylation increases its transcriptional activity through the recruitment of the coactivator PCAF, is required for its transforming activity and leads to its degradation through an ubiquitin/proteasome-dependent pathway.
細胞内局在Nucleus. Detected in nuclei of pancreas islet beta cells.