Recombinant Human Lunatic Fringe protein (ab116899)

製品の概要

  • 製品名Recombinant Human Lunatic Fringe protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q8NES3
    • 生物種Human
    • 配列MTPGRCCLAADIQVETFIFTDGEDEALARHTGNVVITNCSAAHSRQALSC KMAVEYDRFIESGRKWFCHVDDDNYVNLRALLRLLASYPHTRDVYVGKPS LDRPIQAMERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFM NTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTSELHEQ VTLSYGMFENKRNAVHVKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIF
    • 分子量53 kDa including tags
    • 領域1 to 250

特性

Our Abpromise guarantee covers the use of ab116899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • 3-N-acetylglucosaminyltransferase lunatic fringe
    • Beta-1
    • Beta-13-N-acetylglucosaminyltransferase lunatic fringe
    • lfng
    • LFNG_HUMAN
    • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    • SCDO3
    see all
  • 機能Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
  • 関連疾患Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • 配列類似性Belongs to the glycosyltransferase 31 family.
  • 翻訳後修飾A soluble form may be derived from the membrane form by proteolytic processing.
  • 細胞内局在Golgi apparatus membrane.
  • Information by UniProt

Recombinant Human Lunatic Fringe protein 画像

  • 12.5% SDS-PAGE showing ab116899 at approximately 53.24 kDa stained with Coomassie Blue.

Recombinant Human Lunatic Fringe protein (ab116899) 使用論文

ab116899 has not yet been referenced specifically in any publications.

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