Recombinant Human LOX 1 protein (denatured) (ab111627)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P78380
    • 生物種Human
    • 配列MQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIE TLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYL FSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLS RRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCI LAAFSICQKKANLRAQ
    • 分子量25 kDa
    • 領域58 to 273

特性

Our Abpromise guarantee covers the use of ab111627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 5% Glycerol, 2.4% Urea

関連情報

  • 別名
    • C-type lectin domain family 8 member A
    • CLEC8A
    • hLOX 1
    • hLOX-1
    • Lectin like oxidized LDL receptor 1
    • Lectin like oxLDL receptor 1
    • Lectin type oxidized LDL receptor 1
    • Lectin-like oxidized LDL receptor 1
    • Lectin-like oxLDL receptor 1
    • Lectin-type oxidized LDL receptor 1
    • low density lipoprotein oxidized, receptor 1
    • LOX-1
    • LOXIN
    • Olr1
    • OLR1_HUMAN
    • Ox LDL receptor 1
    • Ox-LDL receptor 1
    • Oxidised low density lipoprotein (lectin like) receptor 1
    • Oxidized low density lipoprotein receptor 1
    • Oxidized low density lipoprotein receptor 1 soluble form
    • Oxidized low-density lipoprotein receptor 1
    • SCARE1
    • Scavenger receptor class E, member 1
    • SLOX1
    • soluble form
    • SR-EI
    see all
  • 機能Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • 組織特異性Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
  • 関連疾患Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
    Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.
  • 配列類似性Contains 1 C-type lectin domain.
  • ドメインThe cytoplasmic region is required for subcellular sorting on the cell surface.
    The C-type lectin domain mediates the recognition and binding of oxLDL.
  • 翻訳後修飾The intrachain disulfide-bonds prevent N-glycosylation at some sites.
    N-glycosylated.
  • 細胞内局在Cell membrane. Secreted. A secreted form also exists.
  • Information by UniProt

Recombinant Human LOX 1 protein (denatured) 画像

  • 15% SDS-PAGE showing ab111627 at approximately 24.7kDa (3µg).

Recombinant Human LOX 1 protein (denatured) (ab111627) 使用論文

ab111627 has not yet been referenced specifically in any publications.

Product Wall

I can confirm that the labs have not yet tested these products to determine activity. They have informed me that ab152043 has been tested successfully by a customer however we cannot share the customer's name or data.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"