製品の概要

  • 製品名
    Recombinant Human LLGL1 protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      GIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQA SYRIRESPKLSQANGTPSILLAPQSLDGSPDPAHSMGPDTPEPPEAALSP
    • 分子量
      37 kDa including tags
    • 領域
      911 to 1010

特性

Our Abpromise guarantee covers the use of ab114953 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • DLG4
    • DLG4, formerly
    • HUGL
    • Hugl 1
    • Hugl-1
    • HUGL1
    • Human homolog to the D-lgl gene protein
    • L2GL1_HUMAN
    • Lethal giant larvae homolog 1
    • Lethal giant larvae homolog 1 (Drosophila)
    • Lethal(2) giant larvae protein homolog 1
    • LLGL
    • Llgl1
    • Ly 49G2
    • Ly49G2
    • Mgl1
    • Mlgl
    see all
  • 機能
    Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells.
  • 組織特異性
    Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
  • 配列類似性
    Belongs to the WD repeat L(2)GL family.
    Contains 14 WD repeats.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated at least at Ser-663 by PRKCI.
  • 細胞内局在
    Cytoplasm > cytoskeleton. Localized to the lateral membrane during the polarization and formation cell-cell contacts.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab114953 at approximately 36.63kDa.
    Stained with Coomassie Blue.

参考文献

ab114953 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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