製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号Q15831
    • 生物種Human
    • 分子量85 kDa including tags
    • 領域1 to 433

特性

Our Abpromise guarantee covers the use of ab119736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    The purity was determined to be 90% by densitometry
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.003% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

関連情報

  • 別名
    • hLKB1
    • Liver kinase B1
    • LKB1
    • PJS
    • Polarization related protein LKB1
    • Renal carcinoma antigen NY-REN-19
    • Serine/Threonine Kinase 11
    • Serine/threonine protein kinase 11
    • Serine/threonine protein kinase LKB1
    • Serine/threonine protein kinase STK11
    • Serine/threonine-protein kinase 11
    • Serine/threonine-protein kinase LKB1
    • Serine/threonine-protein kinase XEEK1
    • Stk11
    • STK11_HUMAN
    see all
  • 機能Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
  • 組織特異性Ubiquitously expressed. Strongest expression in testis and fetal liver.
  • 関連疾患Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
    Defects in STK11 have been associated with testicular tumors (TEST) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Phosphorylated by a cAMP-dependent protein kinase.
  • 細胞内局在Nucleus. Cytoplasm. Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
  • Information by UniProt

Recombinant Human LKB1 protein 画像

  • The purity was determined to be >90% by densitometry.

Recombinant Human LKB1 protein (ab119736) 使用論文

ab119736 has not yet been referenced specifically in any publications.

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