製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab59008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 精製度> 95 % SDS-PAGE.
    0.2 µm filtered solution.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Sodium chloride, 25mM HEPES, 1mM DTT, pH 7.5

関連情報

  • 別名
    • Baculoviral IAP repeat containing 7
    • Baculoviral IAP repeat containing protein 7
    • Baculoviral IAP repeat-containing protein 7
    • BIRC 7
    • birc7
    • BIRC7_HUMAN
    • KIAP
    • Kidney inhibitor of apoptosis protein
    • Livin
    • Livin inhibitor of apotosis
    • Melanoma inhibitor of apoptosis protein
    • ML IAP
    • ML-IAP
    • MLIAP
    • RING finger protein 50
    • RNF 50
    • RNF50
    see all
  • 機能Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
  • 組織特異性Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
  • 配列類似性Belongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • 細胞内局在Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
  • Information by UniProt

Recombinant Human Livin protein (ab59008) 使用論文

ab59008 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"