Recombinant Human Lipoamide Dehydrogenase protein (ab116690)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P09622
    • 生物種Human
    • 配列MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMADQ PIDADVTVIG SGPGGYVAAI KAAQLGFKTV CIEKNETLGG TCLNVGCIPS KALLNNSHYY HMAHGKDFAS RGIEMSEVRL NLDKMMEQKS TAVKALTGGI AHLFKQNKVV HVNGYGKITG KNQVTATKAD GGTQVIDTKN ILIATGSEVT PFPGITIDED TIVSSTGALS LKKVPEKMVV IGAGVIGVEL GSVWQRLGAD VTAVEFLGHV GGVGIDMEIS KNFQRILQKQ GFKFKLNTKV TGATKKSDGK IDVSIEAASG GKAEVITCDV LLVCIGRRPF TKNLGLEELG IELDPRGRIP VNTRFQTKIP NIYAIGDVVA GPMLAHKAED EGIICVEGMA GGAVHIDYNC VPSVIYTHPE VAWVGKSEEQ LKEEGIEYKV GKFPFAANSR AKTNADTDGM VKILGQKSTD RVLGAHILGP GAGEMVNEAA LALEYGASCE DIARVCHAHP TLSEAFREAN LAASFGKSIN MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMADQ PIDADVTVIG SGPGGYVAAI KAAQLGFKTV CIEKNETLGG TCLNVGCIPS KALLNNSHYY HMAHGKDFAS RGIEMSEVRL NLDKMMEQKS TAVKALTGGI AHLFKQNKVV HVNGYGKITG KNQVTATKAD GGTQVIDTKN ILIATGSEVT PFPGITIDED TIVSSTGALS LKKVPEKMVV IGAGVIGVEL GSVWQRLGAD VTAVEFLGHV GGVGIDMEIS KNFQRILQKQ GFKFKLNTKV TGATKKSDGK IDVSIEAASG GKAEVITCDV LLVCIGRRPF TKNLGLEELG IELDPRGRIP VNTRFQTKIP NIYAIGDVVA GPMLAHKAED EGIICVEGMA GGAVHIDYNC VPSVIYTHPE VAWVGKSEEQ LKEEGIEYKV GKFPFAANSR AKTNADTDGM VKILGQKSTD RVLGAHILGP GAGEMVNEAA LALEYGASCE DIARVCHAHP TLSEAFREAN LAASFGKSIN F
    • 分子量54 kDa including tags
    • 領域36 to 509
    • タグHis tag N-Terminus
    • 配列の追加情報DLD Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 511 amino acids (36-509 a.a.). DLD is fused to a 37 amino acid His Tag at N-terminus.

特性

Our Abpromise guarantee covers the use of ab116690 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab116690 is purified by proprietary chromatographic techniques.
  • 製品の状態Liquid
  • 備考Although stable at 4°C for 30 days, ab116690 should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.58% Sodium chloride, 10% Glycerol

関連情報

  • 別名
    • Dehydrogenase complex, E3 component
    • Diaphorase
    • Dihydrolipoamide dehydrogenase
    • Dihydrolipoyl dehydrogenase
    • Dihydrolipoyl dehydrogenase mitochondrial
    • dld
    • DLDD
    • DLDH
    • DLDH_HUMAN
    • E3
    • E3 branched chain aplha-keto acid
    • E3 component of pyruvate dehydrogenase
    • E3 component of pyruvate dehydrogenase complex 2 oxo glutarate complex branched chain keto acid dehydrogenase complex
    • GCSL
    • Glycine cleavage system L protein
    • Glycine cleavage system protein L
    • LAD
    • lipoamide dehydrogenase
    • Lipoamide reductase
    • Lipoyl dehydrogenase
    • mitochondrial
    • OTTHUMP00000206744
    • OTTHUMP00000206746
    • OTTHUMP00000206748
    • OTTHUMP00000206749
    • PHE 3
    • PHE3
    • Pyruvate dehydrogenase component E3
    see all
  • 機能Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
  • 関連疾患Note=Defects in DLD are involved in the development of congenital infantile lactic acidosis.
    Defects in DLD are a cause of maple syrup urine disease (MSUD) [MIM:248600]. MSUD is characterized by mental and physical retardation, feeding problems and a maple syrup odor to the urine. The keto acids of the branched-chain amino acids are present in the urine, resulting from a block in oxidative decarboxylation.
  • 配列類似性Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  • 翻訳後修飾Tyrosine phosphorylated.
  • 細胞内局在Mitochondrion matrix.
  • Information by UniProt

Recombinant Human Lipoamide Dehydrogenase protein (ab116690) 使用論文

ab116690 has not yet been referenced specifically in any publications.

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